COVID-19 is a ROS-driven pathology

Author: Anonymous 5zd4gl

Expire: Never

Coronavirus E and 3a proteins are calcium ion channels and promote ER calcium dumping into the intracellular space: https://www.nature.com/articles/s41598-023-31764-9 https://www.nature.com/articles/s42003-022-03670-9 https://www.mdpi.com/1422-0067/25/12/6304 This was also true of SARS: https://www.sciencedirect.com/science/article/pii/S0042682215003566 https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00050/full Intracellular calcium increases ROS production: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556774/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869783/ SARS-CoV-2 suppresses NRF2 activity: https://www.nature.com/articles/s41467-020-18764-3 https://journals.asm.org/doi/10.1128/spectrum.00378-23 Link between NLRP3 inflammasome and IRI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552576/ Bradykinin Storm: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347967/ https://www.nature.com/articles/s41467-022-32922-9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826266/ Treating COVID-19 with Firazyr: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769237 Description of NO/ONOO- vicious cycle: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856065/ COVID-19 patients have low nitric oxide: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788438/ https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00109-8/fulltext https://www.sciencedirect.com/science/article/pii/S2213231721001300 NO is antiviral against SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544093/ https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111989/ https://link.springer.com/article/10.1007/s11356-022-19148-4 NO/ONOO- Cycle Implicated in ME/CFS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096969/ Long COVID is basically ME/CFS: https://www.statnews.com/2023/09/14/long-covid-me-cfs-myalgic-encephalomyelitis-chronic-fatigue/ NRLP3 inflammasome associated with NETosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195330/ COVID-19 is associated with NETosis, as well: https://www.cell.com/iscience/fulltext/S2589-0042(24)00795-8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924116/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334659/ Spike forms amyloid-fibrin microclots: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380922/ https://assets-eu.researchsquare.com/files/rs-2939263/v1_covered_7190a867-1475-4b57-b220-716a953649f1.pdf?c=1684433225 COVID-19 associated with iron overload: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060024/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306200/ V/Q Mismatch: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764889/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689135/ https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A2749 ROS storm in COVID-19 chemically blocks O2 carriage by heme in RBCs by MPO's formation of excess hypochlorous acid: https://www.ijbs.com/v17p0062.htm NRLP3 inflammasome has a role in IRI-induced inflammation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552576/ https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.926895/full https://www.sciencedirect.com/science/article/pii/S0889159120324521?via%3Dihub Mechanism of IRI: https://www.ncbi.nlm.nih.gov/books/NBK534267/ Ultimate pathological fate in COVID-19 is hydroxyl radical formation and ferroptosis: https://www.nature.com/articles/s41419-023-06102-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952002/ https://www.nature.com/articles/s41467-024-48055-0 Fenton reaction: https://www.sciencedirect.com/topics/earth-and-planetary-sciences/fenton-reaction Should have used antioxidants: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773164/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959932/ https://onlinelibrary.wiley.com/doi/10.1002/fft2.207 In summary, intubation without protective antioxidant adjunct therapy basically melted people's lungs with ROS. You're welcome.

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7/19/2024

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