Coronavirus E and 3a proteins are calcium ion channels and promote ER calcium dumping into the intracellular space:
https://www.nature.com/articles/s41598-023-31764-9
https://www.nature.com/articles/s42003-022-03670-9
https://www.mdpi.com/1422-0067/25/12/6304
This was also true of SARS:
https://www.sciencedirect.com/science/article/pii/S0042682215003566
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00050/full
Intracellular calcium increases ROS production:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556774/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869783/
SARS-CoV-2 suppresses NRF2 activity:
https://www.nature.com/articles/s41467-020-18764-3
https://journals.asm.org/doi/10.1128/spectrum.00378-23
Link between NLRP3 inflammasome and IRI:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552576/
Bradykinin Storm:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347967/
https://www.nature.com/articles/s41467-022-32922-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826266/
Treating COVID-19 with Firazyr:
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769237
Description of NO/ONOO- vicious cycle:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856065/
COVID-19 patients have low nitric oxide:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788438/
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00109-8/fulltext
https://www.sciencedirect.com/science/article/pii/S2213231721001300
NO is antiviral against SARS:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544093/
https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111989/
https://link.springer.com/article/10.1007/s11356-022-19148-4
NO/ONOO- Cycle Implicated in ME/CFS:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096969/
Long COVID is basically ME/CFS:
https://www.statnews.com/2023/09/14/long-covid-me-cfs-myalgic-encephalomyelitis-chronic-fatigue/
NRLP3 inflammasome associated with NETosis:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195330/
COVID-19 is associated with NETosis, as well:
https://www.cell.com/iscience/fulltext/S2589-0042(24)00795-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924116/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334659/
Spike forms amyloid-fibrin microclots:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380922/
https://assets-eu.researchsquare.com/files/rs-2939263/v1_covered_7190a867-1475-4b57-b220-716a953649f1.pdf?c=1684433225
COVID-19 associated with iron overload:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060024/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306200/
V/Q Mismatch:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764889/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689135/
https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A2749
ROS storm in COVID-19 chemically blocks O2 carriage by heme in RBCs by MPO's formation of excess hypochlorous acid:
https://www.ijbs.com/v17p0062.htm
NRLP3 inflammasome has a role in IRI-induced inflammation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552576/
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.926895/full
https://www.sciencedirect.com/science/article/pii/S0889159120324521?via%3Dihub
Mechanism of IRI:
https://www.ncbi.nlm.nih.gov/books/NBK534267/
Ultimate pathological fate in COVID-19 is hydroxyl radical formation and ferroptosis:
https://www.nature.com/articles/s41419-023-06102-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952002/
https://www.nature.com/articles/s41467-024-48055-0
Fenton reaction:
https://www.sciencedirect.com/topics/earth-and-planetary-sciences/fenton-reaction
Should have used antioxidants:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773164/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959932/
https://onlinelibrary.wiley.com/doi/10.1002/fft2.207
In summary, intubation without protective antioxidant adjunct therapy basically melted people's lungs with ROS. You're welcome.